Restart Trial

RESTART recruitment closed
Date Posted: 31 May 2018
Recruitment closed at 12pm on 31 May 2018. We have recruited 537 patients. We will complete follow-up at the end of 2018 and plan to present the results of the trial at the 5th European Stroke Organisation Conference in Milan, 22-24 May 2019.

400 not out!
Date Posted: 02 May 2017
Many congratulations to Deborah Howcroft and Dr Lukuman Gbadamoshi at Royal United Hospital, Bath for recruiting the 400th patient to RESTART today – we are now ‘400 not out’ and well on our way to our target of 720 patients by 31 May 2018. Keep up the good work everyone!

Halfway there!
Date Posted: 08 December 2016
Many congratulations to Dr Frances Harrington and her team at Royal Cornwall Hospital for recruiting the 360th patient to RESTART today – we are now half-way to our target of 720 patients by 31 May 2018! Thank you also to the many collaborators who have been busy recruiting in the last month to help us achieve this important landmark before the end of 2016, especially Doncaster (four participants), Northwick Park (three participants), and Hillingdon (two participants).

300th randomisation
Date Posted: 16 May 2016
We are pleased to announce that the 300th patient has just been randomised in RESTART. Many congratulations and thank you to Adrian Barry and Dr Muddegowda for recruiting them, and also to all our collaborators who have helped us achieve this significant milestone.

CHSS funds the pilot phase of RESTART for oral anticoagulants
Date Posted: 26 February 2016
We are delighted to announce that Chest Heart and Stroke Scotland has awarded us a two-year project grant of £89,909 to start a pilot phase of the RESTART for oral anticoagulants (to be known as RESTART-2). Many of our collaborators have asked us for this trial, so we are glad to have finally obtained funding to begin it. We aim to recruit at least 60 participants at the 30 best recruiting (and most interested) RESTART sites. We will be in touch with them shortly.

200th randomisation
Date Posted: 25 September 2015
We are pleased to announce RESTART has recruited its 200th patient to the trial! Thank you and congratulations to all our collaborators who have helped us achieve this noteworthy number.

Resources about clinical trials for patients
Date Posted: 13 September 2015
Patients who are considering joining RESTART (or any other clinical trial) will find our new summary of multimedia information useful. Please visit the patients' page for videos, audio, and leaflets that will help answer patients’ questions about clinical trials.

UK Stroke Forum 2014
Date Posted: 10 November 2014
Stroke physicians, neurologists, and radiologists collaborating with RESTART, or interested in joining the trial, are warmly invited to attend our meeting at the UK Stroke Forum ( on Wednesday 5th December at 13:30-14:10 in the Queens Suite at the conference centre: grab your conference lunch at 13:00 and come along afterwards!

First randomisation
22nd May 2013
Investigators at the Edinburgh Royal Infirmary have randomised the first patient in RESTART!

We've got the green light to start
20th May 2013
On International Clinical Trials Day, ACCORD (the NHS Lothian and University of Edinburgh co-sponsors of RESTART) gave us the 'green light' to start the trial.

Join us at the European Stroke Conference in London
26th April 2013
Come along and say hello at the Edinburgh Stroke Trials stand (413) or at our Collaborators’ meeting on Thursday 30th May 2013 @ 6.15pm in South Gallery Room 31/32 of the ExCeL Centre

RESTART’s protocol is registered
25th April 2013
RESTART is registered with ISRCTN71907627. Please click hereto read the entry on Current Controlled Trials.

Newsletter #1 released
1st April 2013
Click here to download our first newsletter

Date Posted: 14 January 2013
The MHRA has approved RESTART. Two changes to the protocol resulted from their review. Firstly, patients cannot be included if they will be on anticoagulant drugs after randomisation. Secondly, if a participant is randomised to start antiplatelet drugs, the investigator may only choose to start one or more of aspirin, clopidogrel, or dipyridamole.

UK Stroke Forum
Date Posted: 7 November 2012
Stroke physicians, neurologists, and radiologists interested in collaborating with RESTART are warmly invited to attend our meeting at the UK Stroke Forum ( on Wednesday 5th December at 15:45-16:30 in the Ripley Suite at the Holiday Inn.